Figure 1 presents the results of the logistic regression analysis for MDD with the personality polygenic scores based on the GWA meta-analysis as independent variables. Significant positive associations were found between MDD and polygenic N scores for all sets of SNPs. In addition, significant negative associations were found between MDD and polygenic E scores based on the sets of SNPs with P-values <0.1 and <0.5 and polygenic C scores based on the sets of SNPs with P-values <0.3 to <0.5. These effects explained 0.1% of the variance in MDD (P-value <0.05).
