The effects of binge-like alcohol drinking on gene expression have been studied in the Acb of inbred P rats (Rodd et al., 2008), the extended amygdala of P rats (McBride et al., 2010), and several brain regions (olfactory bulb, frontal cortex, striatum, cerebellum, ventral midbrain, and hippocampus) of C57 mice using a single-day procedure (Mulligan et al., 2011). Comparison of the present results with those obtained with the C57 mice or the 2 rat binge-drinking studies did not indicate any overlap in the top annotated genes, with one exception: B2m; beta-2 microglobin was common in the present study and that of Rodd et al., 2008. The lack of overlap likely reflects a combination of factors, such as different regions analyzed, duration and level of binge-like alcohol drinking, time of sampling after ethanol drinking, and, in the case of mice, species differences.
