We scanned the latest genome assemblies of eight species (Arabidopsis thaliana, Caenorhabditis elegans, Ciona intestinalis, Danio rerio, Drosophila melanogaster, Homo sapiens, Mus musculus, and Saccharomyces cerevisiae) with the latest version of all TF binding profiles from the corresponding taxon in the JASPAR CORE collection. This release includes both TF binding profiles for new TFs and trimmed profiles from the previous release to focus on informative positions. Upon comparing genome-wide TFBS predictions using JASPAR 2022 profiles with the corresponding trimmed profiles in JASPAR 2024, we found that most profiles yielded a comparable number of TFBS predictions. However, trimmed profiles predicted more TFBSs overall, with a few exceptions leading to a substantially increased number of predictions (Supplementary Figure S4). Additionally, we relied on the familial binding profiles to merge overlapping TFBSs predicted from similar PFMs. We provide users with the pre-computed TFBS prediction tracks for all TF binding profiles and familial binding profiles for genome visualisation and interpretation; the human and mouse TFBS tracks derived from TF binding profiles in the CORE collection are available as native tracks in the UCSC Genome Browser with prediction scores, logos, and TF names (39).
