Chunk #22 — Materials and methods — Genotyping and CNV analysis — Partitioning the signals in gene sets — Meta-analysis of case–controls

Source

De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia.

Embedded

yes

Text

For meta-analysis combining cases and controls from multiple studies, we included in the above regression models a “study” term added as an N-level factor (where N=number of case/control sets being combined). This makes the analysis robust to differences between studies in chip, analytic method and other study-specific factors.