As an exception among MGE-derived neurons, the long projection SST/NOS1 cells show lower levels of iGluRs and extra- or non-synaptic γ1-containing GABAARs but express a large and unusual set of modulatory receptors including hypocretin, oxytocin, neurokinin, Tacr1 (Figure 4L), which are released from hypothalamic centers that regulate global brain states (Kilduff et al., 2011). These results depict a cell type with weak phasic excitatory and inhibitory inputs but a wide range of tonic subcortical modulatory inputs, consistent with its activation by homeostatic sleep drive and speculated role in regulating global cortical networks (Kilduff et al., 2011) (Table S7).
