across relevant inhibitory circuitry including the bilateral middle frontal gyri, right inferior parietal lobule, left putamen, and left cerebellar tonsil. At the follow-up, AU youth showed the reverse pattern, with relatively greater activation than non-AU youth across task-relevant regions including the bilateral middle frontal gyri, right inferior parietal lobule, and left cerebellum. The authors proposed that differences in brain-based patterns between AU and non-AU youth (particularly less activation in frontoparietal inhibition areas) reflect premorbid brain differences which increase risk for alcohol consumption, that transitions to a pattern of lower engagement of these same critical areas for AU youth. This might reflect problems engaging requisite brain regions involved in stimulus recognition, working memory, and response selection, once alcohol consumption has begun.
