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Chunk #5 — Introduction

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Financial difficulties but not other types of recent negative life events show strong interactions with 5-HTTLPR genotype in the development of depressive symptoms.
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recent life events are lacking. It is also noteworthy that a study found that recent life events specifically related to financial hardships interact with neural nitric oxide synthase polymorphisms in the development of depression, indicating a prominent role for this type of life events in the appearance of depression.37 Therefore, the aim of the present study was to investigate the contribution of different types of recent life events (RLE), related to intimate relationships; financial difficulties; illnesses and injuries; and social network problems to the interaction with the 5-HTTLPR polymorphism in the emergence of depressive symptoms in a large community population recruited from Manchester and Budapest.