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Chunk #9 — PART 1: EMPIRICAL APPRAISAL OF PUBLISHED GWA META-ANALYSES — 1.2. RESULTS

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The power of meta-analysis in genome-wide association studies.
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As of June 15, 2012, the catalog included a total of 1,271 published GWA reports. Of those, 88 reports (references S1-S88; listed in Supplement) included a total of 139 eligible meta-analyses of GWA datasets published between 2009 and 2012 in 20 different journals (Table 1). The majority (44%) of the reports appeared in Nature Genetics, followed by PLoS Genetics (14%), Circulation Cardiovascular Genetics (7%), Human Molecular Genetics (6%), JAMA (5%), and other journals (24%). 106 (76%) meta-analyses pertained to disease phenotypes and 33 (24%) pertained to quantitative traits. The median sample size of these discovery meta-analyses was 20,611 (IQR, 14,392-38,238). The majority (n=109) had been performed in populations of European ancestry, while the remaining had been performed in Asian (n=20), African (n=2) or mixed populations (n=8). Additional replication efforts had been performed for the findings of 101 meta-analyses. The median sample size used in these replication efforts was 16,378 (IQR, 8,112-48,607). The majority (n=81) had been performed in European populations and only 20 had been in populations of non-European ancestries.