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Chunk #22 — Results — The variability of each risk factor can be characterized by a limited set of independent gene expressions — Lipids

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Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.
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ABCA1 and ABCG1 gene expressions were both associated with circulating lipids. The proteins encoded by these genes are key players in reverse cholesterol transport and the regulation of lipid-trafficking mechanisms in macrophages respectively [42], [43]. MYLIP (Idol) is a ligase involved in the ubiquitination and degradation of LDL receptors [44], [45] and SCD is a stearoyl-CoA desaturase involved in the conversion of saturated into monounsaturated fatty acids that regulates lipid metabolism and may be modulated by dietary intake [46].