an additional 8,012 unique global ancestry-associated DEGs (LFSR < 0.05; Supplementary Fig. 2, Supplementary Table 1 and Supplementary Data 1) and 6,629 unique local ancestry-associated DEGs (LFSR < 0.05; Supplementary Table 2 and Supplementary Data 2) in these BAs. Similarly, we found that isoform-level local ancestry differentially expressed features showed a significant positive correlation in effect sizes compared with global ancestry differentially expressed features (Spearman, Supplementary Fig. 3). We also confirmed most of these ancestry-associated DEGs in a binary comparison of BAs and non-Hispanic WAs (Supplementary Note, Supplementary Figs. 42–45 and Supplementary Tables 5 and 6).
