2q35, which has been implicated in linkage studies for alcohol phenotypes, including the CDH13 and ADH1C genes that have been reported to be associated with alcohol dependence (Treutlein et al., 2009). Linkage analysis also detected loci underlying moderate and severe alcoholism implicating chromosome 16 (Foroud et al., 1998). In other studies, patients with carcinoid tumors had frequent history of alcohol consumption (Wang et al., 2005). Allelic loss of chromosome 11q was present in 21% of tumors, chromosome 16q in 13%, and chromosome 18 in 30% (Wang et al., 2005).
