After Bonferroni correction (p < .05/1,547 =3.20e-5), the addiction-rf was genetically correlated with 251 phenotypes (Figure 3; Supplemental Table 18). Notably, 38 of these (15%) included somatic diseases linked to specific substances (e.g., lung cancer with tobacco, and pain-related conditions with opioids). As expected, we found significant genetic correlations between the addiction-rf and serious, trans-diagnostic psychopathological behaviors, including suicide attempt (rg=0.62, p=2.89e-33) and self-medication (e.g., using non-prescribed drugs or alcohol for anxiety, rg=0.64, p=3.18e-6). The addiction-rf was correlated with, but remained separable based on 95% confidence intervals (rg=0.63 ±.037, p=2.33e-231), from an externalizing factor27 that included similar indices of problematic substance use and behavioral measures.
