AUD individuals are also impaired across several measures of decision-making [60, 61]. In the evaluation of risk, AUD individuals showed decreased loss sensitivity in a mixed gamble study [62], which can lead to a change in ongoing behavior. A large meta-analysis of the existing neuroimaging data was used to show that LOFC activity is related to the evaluation of loss [63]. Our results show that the LOFC is also one of the most informative brain regions for classification and prediction. These results indicate that AUD individuals show significant impairment in the evaluation of risks of drinking, and the sensitivity to the negative consequences of alcohol consumption decreases with the increase of the severity of the addiction.
