In recent years, large genome-wide association studies (GWAS) have been conducted to identify genetic risk factors for a vast amount of diseases including coronary artery disease (CAD). These GWAS have successfully identified tens of single-nucleotide polymorphisms (SNPs) located in genes and their vicinity that might play a role in the pathophysiology of CAD. The CARDIoGRAMplusC4D consortium is the largest CAD-GWAS consortium comprising 63,746 CAD cases and 130,681 controls [1]. This consortium has found 46 susceptibility loci significantly associated with the risk of CAD and 104 loci suggestive for CAD (FDR < 0.05).
