It is illustrative to compare the location of a few sets of disorders in genetic versus environmental space. From a genetic perspective, dysthymia sorts with the personality disorders, yet its environmental risk factors place it much closer to major depression. Environmentally, alcohol abuse or dependence shares most risk factors with internalizing disorders but shares genetic risk factors with the axis I externalizing disorders. Environmentally, borderline personality disorder has links with all personality disorders and with axis I internalizing disorders; genetically, it is closely tied to axis I and II externalizing disorders.
