Chunk #62 — 4. WIP1 SUPPRESSES THE STRESS RESPONSE: UPDATE — 4.5. Wip1 attenuates the response to oncogenic stress and promotes tumorigenesis — 4.5.1. Cooperation of Wip1 with oncogenes in tumorigenesis
not overexpressed, whereas mutant p53 frequently is overexpressed (98). On the other hand, and unlike the results of Rauta et al. (98), PPM1D amplification was not correlated with a poor prognosis (107). These results imply that, in addition to PPM1D amplification, up-regulation of Wip1 expression is important in breast cancer and suggest that Wip1 inhibition of p53 may be an important mechanism by which Wip1 promotes breast tumorigenesis.
