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Chunk #66 — Online Methods — Identification and evaluation of candidate tumor purity and ploidy values

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Absolute quantification of somatic DNA alterations in human cancer.
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initiated from all points in a regular lattice spanning the domain of b and δτ. The parameter σP was set to 0.01 for this study. We verified that the above approximation identified modes equivalent to those obtained through a full Metropolis-Hastings Markov chain Monte Carlo (MCMC) simulation (data not shown). The approximation allows for much simpler computations to be used.