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Chunk #10 — ADH Genes and Their Polymorphisms — Other Variations in ADH Genes

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The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants.
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The variations in the coding regions of the ADH genes discussed above account for only a small fraction of the total variability. Researchers have identified approximately 240 SNPs in the region containing the seven ADH genes, most of them in noncoding sequences (i.e., introns) within the genes and in regions flanking the genes. As described later in this section, some of these SNPs affect the level of gene expression.