Chunk #29 — HOW DO NEURAL SIGNATURES ASSOCIATED WITH AUD HELP ELUCIDATE THE ROLE OF BRAIN FUNCTION IN THE RISK AND CONSEQUENCES OF ALCOHOL USE AND AUD ACROSS THE LIFESPAN? — How do genomic factors influence brain functioning across the lifespan and contribute to antecedents and resilience for AUD? — Early linkage and association studies of neurophysiological (endo)phenotypes
have been implicated in large GWAS (>1 million participants) of alcohol consumption, risk‐taking behaviors, and related addictive phenotypes 120 , 121 , 122 (e.g., smoking). Variants in GABRA2 have also been associated with EEG‐based phenotypes, 123 but in relatively smaller samples (>10 thousand participants) given the uniqueness of these datasets.
