We have constructed an integrated model of common and rare variation catalogued from the literature and demonstrated its association with BMI in 1850 European-American and 498 African-American SAGE participants. This study is among the first to incorporate both SNPs and CNVs in a joint genetic analysis of BMI and obesity risk prediction. Our best- fitting model included standard covariates, SNP-GRSS and a 21-kb deletion on 16p12.3, and accounted for 11.5% of the phenotypic variance in BMI (p = 3.34×10−54).
