to code increase and decrease in appetite, weight, sleep and energy level). Latent class cluster models were fit to binary responses for these MDD ‘A’ criteria, and identified three latent classes in MDD cases characterized by weight loss/insomnia, weight gain/insomnia and hypersomnia (see Supplementary Methods for more details). The predominant latent class was consistent with ‘typical’ MDD58,59 and we analyzed cases indexed by this class.
