(Ikonomidou et al. 2000) and regulation of GABAA receptor subunits including a downregulation of α5 expression in brain (Toso et al. 2006), upregulation of the β2/3 subunit in the hippocampus (Iqbal et al. 2004) and upregulation of δ expression and function in cerebellar granule neurons (Diaz et al. 2014), the latter of which was recapitulated in the current study, suggesting that iPSC-models of alcohol exposure early in development could elucidate novel effects of alcohol on relatively immature human neurons.
