that P300 amplitude is an endophenotype for a broad range of disinhibited behavior, of which AAU is just one expression (Carlson et al., 1999; Hicks, et al., 2007; Patrick, et al., 2006). Adolescence is a critical period for brain development (Giedd, 2004), and is often when initial alcohol exposure occurs. Therefore, understanding the impact of AAU on adolescent brain development can help differentiate the effects of AAU from preexisting differences in brain structures or functions that relate to risk for alcohol misuse. Although the present study did not find that AAU affected the heritability of P3AR, additional research is warranted to understand in what ways the adolescent brain may be impacted by AAU.
