Chunk #26 — Materials and Methods — Experimental design and statistical analysis — Mutual information (MI) of individual neurons

Source

Encoding of the Intent to Drink Alcohol by the Prefrontal Cortex Is Blunted in Rats with a Family History of Excessive Drinking.

Embedded

yes

Text

Next, to ensure that non-significant MI values did not inflate the estimates of SE, the p values were used to calculate a weight (w) for each MI result via w = -log10(p). These weights were then normalized by dividing each weight by the sum of all the weights and used to calculate the weighted mean (Eq. 3) and SE of the weighted mean (Eq. 4) across all relevant neurons (animal strain and liquid type) at a given time bin t.(3)I¯t(x,y)=∑iwiIi,t(x,y). (4)SEMt(x,y)=σt∑iwi2.