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Chunk #34 — Methods — Population-wide aspPS analyses

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Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals.
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The true aspPSs were compared with aspPSs of the same individual produced with an incorrect local ancestry pattern with a one-sided Wilcoxon signed-rank test. This control was obtained shuffling the local ancestry patterns among individuals of the same population, excluding the correct pattern-individual matching. The test side was always towards 0 for the reference population and away from 0 otherwise.