The UK Biobank (UKB) is an excellent resource to address these inconsistencies, offering a large, harmonized neuroimaging dataset with a substantial number of APOE ε2 and ε4 allele carriers. The overall UKB cohort comprises > 500,000 community‐based participants aged 40 to 69 who were recruited at baseline assessment between 2006 and 2010. 17 Since 2014, a subset of participants returned for neuroimaging assessments and data are currently available for ≈ 45,000 participants. 18 Leveraging this large, population‐based neuroimaging sample of participants with APOE genotypes ε3/ε3, ε3/ε4, ε4/ε4, and ε2/ε3, our goal is to examine the association of APOE and total hippocampal volume across age and identify the age at which divergence from the ε3/ε3 status becomes detectable.
