The 4–5-year-old aDRG NSCs not only preserve neuroepithelial features and can become neurons and astrocytes, but can also differentiate into sensory neurons as those of eDRG (Table 2). The aDRG NSCs were VGluT2 immunostained as the pan sensory neurons (20,26,37) and were also either TrpV1 or pNF200 immunostained. TrpV1 is known to localize to small and medium, mostly unmyelinated capsaicin-sensitive sensory neurons (4,15,30,38); while the pNF200 corresponds to myelinated, neurofilament-rich, capsaicin-insensitive proprioceptive and mechanoreceptive sensory neurons in DRG (19,24,34).
