Distribution of genetic sum scores based on candidate gene SNPs pruned at r2<0.50 in cases and controls for AD. Left panel: scores in the COGA GWAS sample independent of the COGA high-density family-based association sample. Right panel: scores in the FSCD and COGEND portion of the SAGE GWAS sample. The figure shows the frequency of normalized allele counts in bins separately for cases and controls. Allele counts were created by adding the number of risk alleles of SNPs associated with AD in candidate gene studies, and then dividing by the number of non-missing genotypes for each individual. The table summarizes the mean and range for the sum score in cases and controls.
