The present study used ICA to test for functional connectivity differences between OUD subjects and non-drug using healthy control subjects (HC) within the DMN, SN, and ECN. Previous research using ICA has shown the ECN to be lateralized as left ECN (LECN) and right ECN (RECN) components, and therefore we studied both LECN and RECN components in our ICA analysis [15]. The present study also tested for associations of functional connectivity with negative urgency scores (NU) across all subjects. NU is an aspect of impulsivity, which has been linked to executive control, and is described as the tendency to act rashly in response to negative affect [16,17]. NU has been associated with greater opioid use and future opioid use in a chronic pain patient sample, but has not yet been studied in association with functional connectivity in OUD [18].
