the conclusion that reliability was acceptable when response options are dichotomized (as in the present study). (iv) Using a period of abstinence to allow for dissipation of tolerance as a model for initial sensitivity, we found that retrospective reports of head rush or buzz during early experimentation with smoking predicted significantly which individuals rated re-exposure to nicotine administered via nasal spray as more pleasurable [25]. (v) Studies of various other aspects of smoking behavior [38,39] suggest that self-report of tobacco use is generally reliable.
