paired t-test, p <0.001), from r = 0.81 ± 0.03 to r = 0.13 ± 0.12 (Fig. 5C–E) indicating that nRE contributes to 2–5-Hz synchrony between the PFC-HC, and removal of this influence completely eliminates residual PFC-HC correlation. In contrast, theta PFC-HC correlations (r = 0.65 ± 0.07) and partial correlation (r = 0.61 ± 0.08) were not significantly different (students paired t-test, p = 0.53), suggesting that nRE has minimal effect on theta synchronization between PFC and HC (Fig. 5C–E). Interestingly, HC-nRE theta correlation was lower in this group (p = 0.32, Fig. 5A–B), which was then completely eliminated when controlling for the PFC (partial correlation r(HC-nRE/PFC) = 0.007) indicating that no unique HC-nRE theta coupling existed in these experiments other than that also shared with PFC (Fig. 5E).
