λ1000 of 1.033, while the LDSC intercept was 1.0155 (s. e. = 0.0085), indicating that the inflation was mostly due to polygenic signal and unlikely to be significantly confounded by population structure. The genome-wide significance threshold for the GWAS was set at a P-value of 5.0 × 10−8. The 23andMe data included information on the X-chromosome; as this information was not present for all other cohorts, analysis of the X-chromosome was only conducted in this sub-cohort (see Supplementary Note 4 for details).
