Although screening for MBL outside a research study is not recommended, its incidental detection will continue. Physicians need to be aware that the diagnosis of MBL may lead to unneeded distress and increased health care costs.35 Taken together, these facts emphasize the need for future population-based and preclinical studies designed to improve our understanding of the progression of leukemogenesis, particularly in the early window before the development of clinical CLL.1,36
