where xi is the profile of node i and E(q) is the module eigengene of module q. The module membership measure Kcor,i(q) lies in [-1, 1] and specifies how close node i is to module q, q = 1, . . ., Q. The larger |Kcor,i(q)|, the more similar node i is to the eigengene of the q-th module. In some publications [14,15], Kcor,i(q) is referred to as signed module eigengene (ME) based connectivity measure KME. This is the reason why we named the corresponding R function signedKME.
