et al. 2011) and the original GWAS for alcohol dependence had fewer individuals, it is understandable that the variance explained by PGRS is low. Finally, not all of the associations we report withstand correction for multiple testing. The associations between digit symbol coding, education and alcohol dependence PGRS were modest and do not survive correction for multiple testing across both datasets. However, it is notable that Mill Hill Vocabulary, digit symbol coding and education are nominally associated with alcohol dependence polygenic risk with the same direction of effect observed for each score.
