The neurobiological foundation of these models is mainly based on the results of functional activation studies in human addicts, and the observation that exposure to addictive drugs produces persistent structural and functional changes on cells within this network (Garavan et al., 2000; Goldstein et al., 2007; Kalivas and O'Brien, 2008; Tomasi et al., 2007; Yang et al., 2009). To date, the resting-state functional connectivity within the key regions of drug addiction has not been extensively studied in human addicts. Therefore, in this study, we investigated whether there is any addiction related alteration in resting-state functional connectivity in this network with fMRI data acquired during resting state from chronic heroin users and non-addicted controls.
