Using permutation tests, for the most significant linkage result on chromosome 15 (LOD score = 4.01, p = .00001 for the ASD families with IQ ≥ 70 and LOD score = .08, p = .3 for all the ASD families), the probability that a subset of 313 families randomly selected from all the ASD families could reach a LOD score of 4.01 at this locus was .0006 with a 95% confidence interval of .0004 to .001. For the most significant linkage result on chromosome 11 (LOD score = 3.40, p = .00004 for the ASD families with DelayedPhrase and LOD score = 1.75, p = .002 for all the ASD families), the probability that a subset of 412 families randomly selected from all the ASD families could reach a LOD score of 3.40 at this locus was .03 with a 95% confidence interval of .02 to .05.
