Chunk #55 — DISCUSSION — Implication for future research

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Extending the MR-Egger method for multivariable Mendelian randomization to correct for both measured and unmeasured pleiotropy.

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Throughout the paper, we have assumed that the genetic variants are uncorrelated (not in linkage disequilibrium). This assumption, and the requirement for further methodological development, is discussed in the Web Appendix.