Due to the large sample size of the EA cohort investigated (N=146,660), we observed a consistent polygenic signal in the summary association data (λ=1.20), with negligible inflation observed (LD score regression intercept=1.05±0.01) due to possible confounding factors, including population stratification and the distribution of the reexperiencing items in the cohort investigated (Table S1).. Eight distinct common-variant GWS regions were identified in this ancestry group (Table 1 and Figure 1), three of these with significance p<5×1010. These latter three regions map to chromosome 3, lead SNP rs2777888 (beta=0.111, p=2.1×10−11), gene CAMKV (CaM Kinase Like Vesicle Associated); chromosome 17, lead SNP rs2532252 (beta=0.122, p=4.5×10−10), closest to KANSL1 but within a long high-LD region that also includes CRHR1 (corticotropin releasing hormone receptor 1); and chromosome 18, lead SNP rs2123392 (beta=0.113, p=5.4×10−11), at TCF4 (Transcription Factor 4). Other significant associations were observed at KCNIP4 (Potassium Voltage-Gated Channel Interacting Protein 4, rs4697248: beta=0.105, p=3.73×10−9), HSD17B11 (Hydroxysteroid 17-Beta Dehydrogenase 11, rs7688962: beta=−0.126, p=1.34×10−8), MAD1L1 (MAD1 Mitotic Arrest Deficient Like 1, rs10235664: beta=−0.113, p = 3.09×10−9), SRPK2 (SRSF Protein Kinase 2, rs67529088: beta=−0.09, p=3.32×10−8), and LINC01360 (Long
