The second locus associated with FEV1 was at 2q35, localized to the TNS1 gene (nonsynonymous coding SNP rs2571445, P = 1.11 × 10−12; Table 2 and Fig. 2a). The protein this encodes, tensin-1, is an actin-binding protein that contains Src homology 2 domains, suggesting a role in linking cytoskeletal changes with signal transduction16. Tensin-1 may be functionally involved in cell migration17.
