In marked contrast, we observed significant depletion in heritability for several brain-related traits (for example, education years, smoking initiation, age at smoking onset, schizophrenia and depression; enrichment fold < 1, FDR < 0.05; Fig. 6, Supplementary Fig. 30 and Supplementary Data 10). This depletion aligned with our observations that ancestry-associated DEGs were less associated with the neuronal functions implicated in psychiatric disorders and behavioral traits.
