AUC for the combined PRS revealed the combined effect of PRSs only marginally improved the AUC, similar to recent analyses for coronary artery disease33 and ischemic stroke34. We ran a series of sensitivity analyses to test whether differences across the samples reflected age differences rather than differences in ascertainment. Restricting COGA to participants under 30 did not fundamentally change the results (see Supplementary information Section 4, Table S3, and Fig. S4). Evaluating the AUC for the combined PRS revealed the combined effect of PRSs only marginally improved the AUC over models with just covariates.
