Although we were not able to examine TS subgroups, we were able to examine the polygenic composition within OCD subgroups (i.e., OCD +/− TS/CT). These results clearly suggest that OCD with and without chronic tics have different genetic architectures. When OCD cases with co-occurring TS/CT were added to the OCD discovery sample, the polygenic signal in the independent OCD target sample was attenuated by 35% (permutation p=0.01), despite the 30% increase in sample size. Similarly, the risk score elevation between transmitted and untransmitted alleles dropped substantially with the addition of these 345 OCD cases with TS/CT (p=0.022).
