BRG1 and BAF complexes might also be necessary for the induction of differentiation into skeletal muscle, given that the ability of the myogenic transcription factors MYOD1 and MEF2D to transactivate myogenic genes in mice was found to be inhibited by a dominant-negative allele of Brg1 (ref. 50) and also by short-hairpin-RNA-mediated depletion of BAF60C40.
