Chunk #19 — MATERIALS AND METHODS — Collaborative Study on the Genetics of Alcoholism — Genome-wide association studies and meta-analysis:

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Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria.

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variants (p <5E-8) were evaluated in replication samples. As we tested seven individual criteria for the tertiary analyses, a matrix of the phenotypic correlations between these criteria in the EA participants (Supplemental Table 1B) was spectrally decomposed using matSpD 43,44 resulting in 3 effectively independent tests and thus a revised GWS p value threshold of 1.67E-8 was used for the tertiary analyses.