2009). Notably, one of the zebrafish nSMase identified was localized to the mitochondria (Yabu et al., 2008), an important organelle for sphingolipid metabolism (Birbes et al., 2002; Futerman, 2006; Novgorodov and Gudz, 2009). This raises the possibility of additional unidentified mammalian N-SMases. Together, these enzymes comprise the N-SMase family. Notably, the existence of multiple nSMase isoforms is in agreement with studies reporting multiple N-SMase activities reported in bovine brain (Jung et al., 2000).
