Mice deficient in PTPRD show impairment in learning and memory tasks, especially spatial learning, and exhibit enhanced long-term potentiation (LTP), a form of activity dependent plasticity 47. This is relevant to OCD, in that memory deficits have been reported for this condition 48. PTPRD also has been shown to be associated with restless leg syndrome (RLS) 49 and hemizygous deletions were detected in four unrelated attention deficit hyperactivity disorder (ADHD) probands 50.
