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Chunk #39 — Discussion

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Power and predictive accuracy of polygenic risk scores.
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of effect heterogeneity that are not addressed here. Recent estimates of the proportion of markers having effects also suggest that the more optimistic scenarios shown in Table 4, Table 5, Table 6 may apply [9], [33]. Although the focus here is on AUC, various other measures of predictive accuracy are possible and can be computed within the same framework [24], [25]. The expressions given here could be adapted to other measures without much difficulty.