We compared the correlation of genotypes between the exome-sequencing data released by the UK Biobank (following their SPB pipeline113) and the TOPMed-imputed genotypes. The comparison assessed 49,819 individuals and 3,052,260 autosomal variants that were found in both the exome-sequencing and TOPMed-imputed datasets (matched by chromosome, position and alleles, and with an imputation quality of at least 0.3 in the TOPMed-imputed data). We split the variants into MAF bins for which the MAF from the exome data was used to define the bins, and computed Pearson correlations averaged within each bin.
