al., 2007; Li et al., 2008; Druesne-Pecollo et al., 2009). The geographic distribution of esophageal cancer, with its much higher frequencies in individuals of East Asian ancestry (Parkin et al., 1997), suggests a potential association of this cancer to ALDH2*504Lys. The association is believed to be mediated through levels of acetaldehyde following drinking alcohol. The hypothesis is supported by associations of variants at two different ADH genes (Hashibi et al., 2008).
